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Photo: VCG
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Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。    University institutions all over the world are interested in ambitious applicants and always help students adapt to a new place. They are welcomed. Young academics who have chosen education in Russia have shared their experience of studying abroad. They talked about their achievements and how their life and work at South Ural State University (SUSU) is arranged.,Dr. Bagaleu Uday from Warangal, India Came to Russia in 2018,© Bagaleu Uday/Personal archiveBagaleu Uday Bagaleu Uday © Bagaleu Uday/Personal archive,I have been living in Chelyabinsk for three and a half years now. After defending my thesis in chemical engineering at the National Institute of Technology Warangal, India, I decided to continue my research in another country. And when I heard about the latest Russian developments in the field of biotechnology, I had a burning desire to work at SUSU.,For a scientist, moving to another country is a great opportunity to raise his scientific work to a higher level. I learned a lot in the field of food and biotechnology and can now compete with strong researchers. Moreover, because of the education and experience I gained in India, I have been offered an interesting job in the field of packaging material development.,Now I am a senior researcher at the SUSU Department of Food and Biotechnology. This year alone, I have had four publications in Scopus magazine (Scopus is a unified international scientific database - ed. note Sputnik). It was also a great achievement for me to win the young scientist competition. I won a three-year grant to develop a double food-enriching emulsion.,To be honest, I never had any acute feelings about leaving my country. In fact, I consider Chelyabinsk my second home. As long as I work or do my research, I feel comfortable here. My instructor and lab colleagues are always there for me, whether it's my work or just a walk through the city. Furthermore, SUSU launched English-language programs last year. The language will help in traveling abroad to build up my research work. I think science is the only field where people from all the countries can work together to make progress around the world. Science knows no borders.,Uvindu Wijeweera, Postgraduate Student, President of the South Ural Association of International Students and Alumni,I come from Sri Lanka, but I have been studying at SUSU for seven years: I completed my bachelor's and master's degrees in political theory and now I am a postgraduate student in my final year. My research work and future career are closely connected with history. And I am very interested in studying and analyzing the development of other countries, it is very important for a political scientist. Even as a child, I read a lot about Russian literature and, of course, in the end I wanted to see everything with my own eyes. My parents also inspired me to go to another country: my father received part of his education abroad.,In addition to a good political science education, my university invests in the recreation, sports, and social life of its students. I think this is an especially important point for humanitarian professionals on their way to harmonious and well-rounded development, and it is also of great interest to students from other countries. When I came to SUSU, they helped me adapt: they helped me to understand everyday problems and to get acquainted with the culture and classmates. Many foreigners study in English programs or study the first year in Russian at a preparatory faculty. By the way, most of the guys from other countries have never seen winter. It was in Chelyabinsk that I saw snow for the first time in my life.,The experience of working at the international student association has helped me a lot in my studies and academics. Political science is a public science, often public and communication-driven, so a leadership position has proven to be a good place to practice my communication skills.,In general, it seems to me that going through one of the stages of education abroad is a good decision for today's student. This is a great opportunity to get to know a new culture and country. Talent is appreciated in all corners of the planet, and if you have the desire to develop in big steps, the desire to work at the international level, it is worth thinking about discovering this huge world for yourself as early as possible: start from your desires and choose the best of the options.,South Ural State University English-Taught Programs,The official Telegram channel of South Ural State University。

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